Measurement of blood flow in skin with an intact vascular pedicle
| Autor: | Malcolm R. Powell, Samuel L. Kountz, Fred S. Marcus, Sang-In Cho |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Graft Rejection
Skin transplant Groin Vascular pedicle business.industry medicine.medical_treatment Dermatology Anatomy Blood flow Models Biological medicine.anatomical_structure 133xe clearance Regional Blood Flow medicine Animals Transplantation Homologous Vein business Radionuclide Imaging Saline Xenon Radioisotopes Artery Skin |
| Zdroj: | International journal of dermatology. 15(2) |
| ISSN: | 0011-9059 |
| Popis: | An experimental model was devised to confirm directly the validity of total skin blood flow measurement, as postulated by Sejrsen. A section of skin in the groin of the rat was prepared, which contained an intact artery and vein. Both of these were direct branches of the femoral vessels. When 133Xe was injected intrader-mally in saline solution, it was demonstrated that a sham isolated vascular pedicle cleared the isotope, and that the clearance was biexponential, suggesting two compartments. When the vascular pedicle was ligated, thereby removing direct blood flow to the piece of skin, the 133Xe clearance curve was mono exponential. It is concluded that the rapid portion of the bi exponential clearance curve, as analyzed by Sejrsen, does represent the dermal vascular components of isotope clearance, and that measurement of cutaneous blood flow by this method is a valid and useful technique. Results using this technique to follow rejection in a new skin transplant model are presented. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text