Differential Response Profiles in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder
| Autor: | Linda Wietecha, Keith E. Saylor, Kathleen Day, Shufang Wang, Sheng Hu Wu, Doug Kelsey |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Adolescent Atomoxetine Hydrochloride Severity of Illness Index Double-Blind Method Rating scale Post-hoc analysis Humans Medicine Attention deficit hyperactivity disorder Sex Distribution Child Psychiatry Adrenergic Uptake Inhibitors Propylamines business.industry Atomoxetine medicine.disease Clinical trial Treatment Outcome Attention Deficit Disorder with Hyperactivity Pediatrics Perinatology and Child Health Mixture modeling Female business medicine.drug |
| Zdroj: | Clinical Pediatrics. 54:164-173 |
| ISSN: | 1938-2707 0009-9228 |
| DOI: | 10.1177/0009922814555973 |
| Popis: | Atomoxetine has been shown to be safe and effective in the treatment of attention-deficit/hyperactivity disorder (ADHD). The purpose of this post hoc analysis was to examine response trajectories of pediatric patients treated with atomoxetine. Data were pooled from 7 atomoxetine double-blind, placebo-controlled clinical trials conducted in pediatric patients between November 1998 and June 2004. Growth mixture modeling was applied to the investigator-rated ADHD rating scale (ADHDRS-Inv) and Clinical Global Impressions-ADHD-Severity (CGI-ADHD-S) scores in the randomized acute phase (6-9 weeks) to explore whether there were groups of patients who differed in their response to atomoxetine. Classification and regression tree analyses were performed to identify predictors that can help categorize subjects to different response profiles. Patients (N = 925) were mostly male (73%) and of the combined subtype (74%). Most patients had a response pattern characterized by gradual, modest improvement, while a smaller group experienced early, robust improvement. |
| Databáze: | OpenAIRE |
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