Intracellular diacylglycerol: a mitogenic second messenger proposable as marker of transformation in squamous cell carcinoma of the lung
| Autor: | Alberto Dragotto, Marco Ruggiero, Stefania Pacini, Franco Casamassima, Vincenzo Chiarugi, Mario Anichini |
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| Rok vydání: | 1996 |
| Předmět: |
Intracellular Fluid
Male Pulmonary and Respiratory Medicine Cancer Research Pathology medicine.medical_specialty Lung Neoplasms Second Messenger Systems Diglycerides Biomarkers Tumor medicine Humans Lung cancer Aged Diacylglycerol kinase Aged 80 and over Bronchus Lung Squamous-cell carcinoma of the lung business.industry Cancer Middle Aged respiratory system medicine.disease respiratory tract diseases Cell Transformation Neoplastic medicine.anatomical_structure Oncology Epidermoid carcinoma Second messenger system Carcinoma Squamous Cell Female business Bronchoalveolar Lavage Fluid |
| Zdroj: | Lung Cancer. 15:161-170 |
| ISSN: | 0169-5002 |
| DOI: | 10.1016/0169-5002(96)00579-x |
| Popis: | In this study, we examined 50 patients with documented lung cancer projecting in the bronchial lumen unilaterally. Bronchial lavage from the affected and unaffected sides provided neoplastic and normal cells in which we studied an intracellular mitogenic second messenger, diacylglycerol, associated with transformation. The levels of diacylglycerol in cells from the affected side were compared with that from the healthy side, thus providing an internal control for each patient. Our data show that the levels of diacylglycerol in lavage fluid relative to affected bronchus are elevated in 56% of all the patients examined. This elevation reaches 77% in patients with squamous cell carcinoma, a value of sensitivity higher than 'traditional' markers for cancer of the lung. Thus, these findings may have significant implications for the use of diacylglycerol measurement as a novel biomarker for early detection of lung cancer, and for monitoring recurrences after treatment. |
| Databáze: | OpenAIRE |
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