Monoclonal B-cell lymphocytosis as a biomarker in environmental health studies
| Autor: | Jeffrey A. Lybarger, Patricia A. Buffler, Youn K. Shim, Robert F. Vogt, Gerald E. Marti, Sharon Campolucci, Dannie C. Middleton |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Lymphocytosis Chronic lymphocytic leukemia Population chemical and pharmacologic phenomena Hazardous Substances Internal medicine Environmental health Epidemiology Prevalence medicine Humans education Aged B-Lymphocytes education.field_of_study Hematology business.industry Middle Aged bacterial infections and mycoses medicine.disease Leukemia Lymphocytic Chronic B-Cell Epidemiological Monitoring Immunology Monoclonal Monoclonal B-cell lymphocytosis Biomarker (medicine) Female medicine.symptom business Environmental Health Environmental Monitoring |
| Zdroj: | British Journal of Haematology. 139:690-700 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.2007.06861.x |
| Popis: | The first studies of monoclonal B-cell lymphocytosis (MBL) in the general population were conducted as part of environmental health investigations that began in 1991. MBL was observed as an unexpected finding when blood samples were immunophenotyped by two-colour flow cytometric methods in common use at that time. The initial observations led to a workshop in 1995, at which case definitions were considered and medical follow-up investigations were recommended. Medical follow-ups were conducted in 1997 and 2003. A total of eight cases of confirmed MBL and three cases of presumptive MBL were identified. This review summarizes the findings from those investigations and discusses the issues related to using MBL as a biomarker in environmental health research and population-based studies. |
| Databáze: | OpenAIRE |
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