Functional analysis of CD8 lymphocytes in long-term surviving patients after bone marrow transplantation
| Autor: | J. P. Vernant, N Oudhriri, Beaujan F, M. F. Gourdin, Felix Reyes, Jean-Pierre Farcet, Zohair M, Marine Divine, Lecouedic Jp, T Henni |
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| Rok vydání: | 1988 |
| Předmět: |
Interleukin 2
Cellular immunity Receptor expression Immunology Receptors Antigen T-Cell chemical and pharmacologic phenomena Biology Lymphocyte Activation T-Lymphocytes Regulatory Bone Marrow medicine Humans Immunology and Allergy Cytotoxic T cell Receptors Immunologic Bone Marrow Transplantation Leukemia Receptors Interleukin-2 T-Lymphocytes Helper-Inducer T lymphocyte Mixed lymphocyte reaction medicine.anatomical_structure Bone marrow Lymphocyte Culture Test Mixed CD8 T-Lymphocytes Cytotoxic medicine.drug |
| Zdroj: | Journal of Clinical Immunology. 8:140-147 |
| ISSN: | 1573-2592 0271-9142 |
| Popis: | The recovery of T-cell populations after bone marrow transplantation (BMT) is characterized by a persistent expansion of CD8 lymphocytes. Previously, we have shown that beyond 1 year posttransplantation the CD8 lymphocytes consist, to a large extent, of CD8+ HNK1+ cells that suppress, like normal CD8 lymphocytes, immunoglobulin production in vitro. We have further investigated the functional capabilities of CD8 lymphocytes, mostly HNK1+ (from 50 to 77%), in seven long-term BMT patients. As normal, patient CD8 lymphocytes do not suppress (1) phytohemagglutinin (PHA)-induced interleukin 2 (IL2) receptor expression and IL2 responsiveness by normal T cells or (2) the mixed lymphocyte reaction of donor cells. Also as normal, patient CD8 lymphocytes can be activated into potent cytotoxic effectors. Therefore, under the present experimental conditions, the increase in the absolute number of CD8 lymphocytes in the long-term BMT patients is characterized by an expansion of the CD8+ HNK1+-cell subpopulation and a normal suppressor/cytotoxic potential on a per-CD8+ cell basis. |
| Databáze: | OpenAIRE |
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