Identification of the exon structure and four alternative transcripts of the thyroglobulin-encoding gene
| Autor: | Fabien Bertaux, Michéle Noel, Philippe Fragu, F. Lasmoles |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_treatment
Molecular Sequence Data Biology Thyroglobulin Exon Complementary DNA Genetics medicine Humans Nucleotide Tissue Distribution RNA Messenger Gene chemistry.chemical_classification Base Sequence Alternative splicing Intron Gene Amplification General Medicine Exons Sequence Analysis DNA Molecular biology Introns Alternative Splicing chemistry RNA splicing |
| Zdroj: | Gene. 156(2) |
| ISSN: | 0378-1119 |
| Popis: | The human thyroglobulin (hTg)-encoding gene is a single-copy gene of more than 300 kb and composed of at least 42 exons. After studying the 5' portion of the Tg cDNA (from nucleotides (nt) 1 to 842), we have previously suggested the existence of alternative splicing of the hTg pre-mRNA in human thyroid tissue. Here, we describe four alternative splicings in the central region of the hTg pre-mRNA between nt 3597 and 4653. We have deduced from these results the exonic structure of this region (exons 16 to 22). Finally, the identification of alternative splicings has also allowed us to demonstrate the existence of a strong 5′ splice site inside intron 16 of Tg . |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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