Is the effect of surface modifying molecules on antibacterial activity universal for a given material?
| Autor: | Angel P. Y. Ma, Frederick C. Leung, Aleksandra B. Djurišić, Hung Kay Lee, Wai Kin Chan, Fangzhou Liu, Yu Hang Leung, Alexander Hsu |
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| Rok vydání: | 2014 |
| Předmět: |
Surface (mathematics)
Materials science Cell Survival Surface Properties Significant difference Oxide Nanoparticle Metal Nanoparticles Nanotechnology Drug Synergism Nanomaterials Anti-Bacterial Agents chemistry.chemical_compound Chemical engineering chemistry Coated Materials Biocompatible Drug Stability Materials Testing Escherichia coli Molecule General Materials Science Modifier attachment Particle Size Zinc Oxide Antibacterial activity |
| Zdroj: | Nanoscale. 6(17) |
| ISSN: | 2040-3372 |
| Popis: | Antibacterial activity of nanomaterials is strongly dependent on their properties, and their stability and toxicity can be varied using surface coatings. We investigated the effect of different surface modifying molecules on the antibacterial properties of two ZnO nanoparticle samples. We found that the starting surface properties of the nanoparticles have significant effects on the attachment of the surface modifying molecules and consequent antibacterial activity. Two out of five investigated surface modifying molecules not only had a significant difference in the magnitude of their effect on different nanoparticles, but also resulted in the opposite effects on two ZnO nanoparticle samples (an enhancement of antibacterial activity for one and a reduction of antibacterial activity for the other ZnO sample). This indicates that no general rule on the effect of a specific molecule on the toxicity of a metal oxide nanoparticle can be derived without knowing the nanoparticle properties, due to the fact that surface modifier attachment onto the surface is affected by the initial surface properties. |
| Databáze: | OpenAIRE |
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