Interleukin-6-producing Intravascular Large B-cell Lymphoma with Lymphadenopathy Mimicking the Histology of Multicentric Castleman Disease
| Autor: | Kohei Shiroshita, Yasufumi Masaki, Hidenori Kasahara, Mikio Okayama, Shinichiro Okamoto, Nozomu Kurose, Taku Kikuchi, Takayuki Shimizu, Takahiro Kamiya |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
multicentric Castleman disease
Pathology medicine.medical_specialty Lymphadenopathy Case Report 030204 cardiovascular system & hematology Plasma cell paraneoplastic syndrome Diagnosis Differential 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Biopsy Internal Medicine Humans Medicine Lymph node Aged B-Lymphocytes Intravascular large B-cell lymphoma biology medicine.diagnostic_test Interleukin-6 business.industry Castleman Disease intravascular large B-cell lymphoma Germinal center General Medicine medicine.disease Lymphoma medicine.anatomical_structure biology.protein Prednisolone Female 030211 gastroenterology & hepatology Lymph Nodes Lymphoma Large B-Cell Diffuse Antibody business medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.5046-20 |
| Popis: | An inguinal lymph node biopsy of a woman with a one-month history of a progressive fever, fatigue, dyspnea, skin rash, and lymphadenopathy revealed a well-preserved basic structure, hyperplastic germinal centers, and an interfollicular region containing polyclonal plasma cell sheets, suggesting plasma cell-type multicentric Castleman disease (MCD). We initiated prednisolone and anti-interleukin (IL)-6 antibody (tocilizumab), without success. A biopsy specimen re-evaluation detected CD20-positive atypical large B cells infiltrating the small vessels within and around the lymph node and its capsule. We diagnosed her with intravascular large B-cell lymphoma (IVLBCL). Lymphoma cells were weakly positive for IL-6 by immunohistochemical staining. IL-6 from lymphoma cells may have caused the MCD-like presentation as a paraneoplastic etiology. Malignant lymphoma should be excluded before diagnosing MCD. |
| Databáze: | OpenAIRE |
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