Endometrial and cervical cancer patients with multiple sentinel lymph nodes at laparoscopic ICG mapping: How many are enough?

Autor: Sara Imboden, Maria Luisa Gasparri, Franziska Siegenthaler, Michael D. Mueller, Anja Fink, Andrea Papadia
Rok vydání: 2016
Předmět:
Adult
Indocyanine Green
Cancer Research
medicine.medical_specialty
cervical cancer
medicine.medical_treatment
Sentinel lymph node
Uterine Cervical Neoplasms
sentinel lymph node mapping
610 Medicine & health
Context (language use)
endometrial cancer
ndocyanine green
sentinel lymph node count
echelon lymph nodes
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Humans
030212 general & internal medicine
Aged
Retrospective Studies
Aged
80 and over
Cervical cancer
Sentinel Lymph Node Biopsy
business.industry
Endometrial cancer
General Medicine
Middle Aged
medicine.disease
Endometrial Neoplasms
Surgery
body regions
Oncology
chemistry
030220 oncology & carcinogenesis
Female
Laparoscopy
Lymphadenectomy
Radiology
Lymph
Detection rate
business
Indocyanine green
Zdroj: Papadia, Andrea; Imboden, Sara; Gasparri, Maria Luisa; Siegenthaler, Franziska Anna; Fink, Anja; Mueller, Michael (2016). Endometrial and cervical cancer patients with multiple sentinel lymph nodes at laparoscopic ICG mapping: How many are enough? Journal of cancer research and clinical oncology, 142(8), pp. 1831-1836. Springer 10.1007/s00432-016-2193-5
ISSN: 1432-1335
0171-5216
DOI: 10.1007/s00432-016-2193-5
Popis: PURPOSE The adoption of a sentinel lymph node (SLN) algorithm and the presence of high bilateral detection rates have been associated with increased accuracy of SLN mapping in cervical and endometrial cancer patients. In this context, the significance of the number of SLNs removed has not yet been investigated. The aim of this study was to evaluate (a) whether or not a higher SLN removal count is associated with a reduced false-negative rate and (b) which clinical factors correlate with the number of SLNs removed. METHODS Patients with cervical or endometrial cancer who underwent SLN mapping with bilateral SLN detection followed by lymphadenectomy were evaluated retrospectively. On the basis of the mean number of the SLNs removed, the patients were divided in two groups: Group 1 included patients with up to 3 SLNs removed and Group 2 included patients with more than 3 SLNs removed. Factors predicting a higher SLN count were evaluated using univariate and multivariate analysis. RESULTS Eighty-four patients met the inclusion criteria. The two groups consisted of 42 patients each and differed only by the median SLN count. Two endometrial cancer patients in Group 1 had false-negative pelvic SLNs and isolated para-aortic metastases; no false-negative SLNs were recorded in Group 2 (p = n.s.). The results of multivariate analysis indicted that the number of SLNs removed was influenced only in cases where the operating surgeon had performed more than 20 laparoscopic ICG SLN mappings. CONCLUSIONS A higher SLN count does not seem to increase the accuracy of SLN mapping in cervical and endometrial cancer patients.
Databáze: OpenAIRE
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