Effect of denture liners surface modification with Equisetum giganteum and Punica granatum on Candida albicans biofilm inhibition
| Autor: | Cindy Ruiz Garcia, Thaís Yumi Ueda, Rafaela Alves da Silva, Isadora Prado Cano, Luiz Leonardo Saldanha, Anne Lígia Dokkedal, Vinicius Carvalho Porto, Vanessa Migliorini Urban, Karin Hermana Neppelenbroek |
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| Přispěvatelé: | Universidade de São Paulo (USP), Universidade Estadual Paulista (UNESP), Universidade Estadual de Ponta Grossa (UEPG) |
| Rok vydání: | 2022 |
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| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2022-04-28T19:51:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Aim: This study investigated the effect of denture liners surface modification with Equisetum giganteum (EG) and Punica granatum (PG) on Candida albicans biofilm inhibition supposing its usage as a sustained-release therapeutical delivery system for Candida-associated denture stomatitis. Materials & methods:C. albicans biofilm (SC5314 or ATCC 90028) was formed on soft liners superficially modified by a primer mixed to drugs at minimum inhibitory concentrations (0.100 g for EG and PG or 0.016 g for nystatin per ml of primer). After 24 h, 7 or 14 days, antibiofilm activity was evaluated by colony-forming unit counts. Results: Not all groups were equi-efficient to nystatin after 24 h and 7 days. After 14 days, EG and PG efficacies were not different from nystatin (almost 100% inhibition). Conclusion: The proposed protocol presents a promising option to allopathic drugs for Candida-associated denture stomatitis treatment. Department of Prosthodontics & Periodontics Bauru School of Dentistry University of São Paulo (USP) Department of Surgery Stomatology Pathology & Radiology Bauru School of Dentistry University of São Paulo (USP) Department of Biological Sciences São Paulo State University (UNESP) Department of Dentistry State University of Ponta Grossa (UEPG) PR Department of Biological Sciences São Paulo State University (UNESP) FAPESP: 2016/08702-2, 2017/07314-1 |
| Databáze: | OpenAIRE |
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