Serum oxidized albumin and cardiovascular mortality in normoalbuminemic hemodialysis patients: a cohort study

Autor: Chan Hsu Chen, Yuan-Chuan Kuo, Yachung Jeng, Ming Ying Wu, Chia-San Liu, Shiaw-Wen Chien, Mei-Ann Pai, Paik Seong Lim, Hung Ping Chen, Tsai-Kun Wu
Rok vydání: 2013
Předmět:
Male
Epidemiology
medicine.medical_treatment
lcsh:Medicine
Cardiovascular
Gastroenterology
Biochemistry
Cohort Studies
Chronic Kidney Disease
Clinical Epidemiology
lcsh:Science
Child
Multidisciplinary
biology
Mortality rate
Middle Aged
Human serum albumin
Cardiovascular Diseases
Nephrology
Child
Preschool
Cohort
Blood Chemistry
Medicine
Female
Hemodialysis
Oxidation-Reduction
medicine.drug
Cohort study
Research Article
Adult
medicine.medical_specialty
Adolescent
Clinical Research Design
Serum albumin
Young Adult
Renal Dialysis
Internal medicine
medicine
Humans
Biology
Serum Albumin
Cardiovascular Disease Epidemiology
Aged
Proportional Hazards Models
Retrospective Studies
Plasma Proteins
business.industry
lcsh:R
Albumin
Infant
Proteins
Retrospective cohort study
Oxidative Stress
Immunology
biology.protein
lcsh:Q
business
Dialysis
Zdroj: PLoS ONE
PLoS ONE, Vol 8, Iss 7, p e70822 (2013)
ISSN: 1932-6203
Popis: Background Substantial evidence suggests that increased oxidative stress in hemodialysis (HD) patients may contribute to cardiovascular complications. Oxidative modifications of human serum albumin (HSA), the largest thiol pool in plasma, alter its biological properties and may affect its antioxidant potential in HD patients. Methods We conducted a long-term follow-up study in a cohort of normoalbuminemic HD patients to examine the impact of redox state of serum albumin on patients’ survival by measuring the human nonmercaptoalbumin (HNA) fraction of HSA. Results After adjusting for potential demographic, anthropometric, and clinical confounders, a positive association of HNA level with the risk of death from cardiovascular disease (CVD) and all-cause mortality was observed in normoalbuminemic HD patients. Using stratified analysis, we found a stronger association between HNA level and the risk of death from CVD and all-cause mortality in patients with pre-existing CVD. Conclusions Serum HNA level is a positive predictor of mortality in normoalbuminemic HD patients, especially among those with pre-existing CVD. Increased oxidative stress resulting from biological changes in serum albumin levels could contribute to accelerated atherosclerosis and the development of cardiovascular disease in HD patients.
Databáze: OpenAIRE
Externí odkaz: