Questionnaire-based assessment of sleep disorders in an adult population of Tuberous Sclerosis Complex
| Autor: | Romina Moavero, Alessandra Voci, Andrea Romigi, Francesca Bisulli, Concetta Luisi, Sara Matricardi, Francesca La Briola, Luigi Mazzone, Massimiliano Valeriani, Paolo Curatolo, Oliviero Bruni |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Epilepsy sleep wake disorders adult Tuberous sclerosis General Medicine Tuberous Sclerosis/complications Sleep disorders tuberous sclerosis Epilepsy/epidemiology Adults epilepsy neuropsychiatric disorders sleep sleep disorders humans surveys and questionnaires Sleep Wake Disorders/epidemiology Surveys and Questionnaires Humans Sleep Neuropsychiatric disorders |
| Zdroj: | Moavero, R, Voci, A, Romigi, A, Bisulli, F, Luisi, C, Matricardi, S, La Briola, F, Mazzone, L, Valeriani, M, Curatolo, P & Bruni, O 2022, ' Questionnaire-based assessment of sleep disorders in an adult population of Tuberous Sclerosis Complex ', Sleep Medicine, vol. 92, pp. 81-87 . https://doi.org/10.1016/j.sleep.2022.03.006 |
| Popis: | BACKGROUND AND OBJECTIVE: Tuberous Sclerosis Complex (TSC) is a rare systemic disease with a high prevalence of sleep disorders (SD), although they are still largely under-recognized. The objective of this study was to assess the prevalence of SD in adult patients with TSC, and to evaluate the relationship between sleep, epilepsy, and TSC associated neuropsychiatric disorders (TAND).MATERIALS AND METHODS: We administered Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI) and Epworth Sleepiness Scale (ESS) to 114 adult patients referring to different Italian centers. We also collected information on epilepsy and TAND.RESULTS: PSQI, ISI, and ESS revealed a positive score, respectively, in 52 (46.0%), 30 (26.5%), and 16 (14.1%) patients. PSQI was positive in 26.7% of seizure free patients versus 61.9% with active epilepsy (p = 0.003), and the association remained significative applying a multivariate logistic model considering age, antiseizure medications, TAND and nocturnal epileptic seizures (p = 0.02). ISI was positive in 3.3% of seizure free patients versus 41.3% with active epilepsy (p = 0.0004). Applying a multivariate logistic model with the independent variables listed above, the association remained significant (p = 0.007). On the other hand, multivariate logistic model considering active epilepsy as an independent variable, revealed that TAND didn't appear a significant risk factor for positive PSQI (p = 0.43) nor ISI (p = 0.09).CONCLUSIONS: Our results confirmed that SD are highly prevalent in adults with TSC, with active epilepsy acting as a significant risk factor. A careful assessment of sleep, above all in epileptic patients, is of crucial importance. |
| Databáze: | OpenAIRE |
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