Mechanisms regulating immune surveillance of cellular stress in cancer
| Autor: | Stephen Searles, Jack D. Bui, Ruth Seelige |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
DNA damage Mitosis Biology medicine.disease_cause 03 medical and health sciences Cellular and Molecular Neuroscience Immune system Neoplasms medicine Animals Humans Immunologic Surveillance Molecular Biology Pharmacology Tumor microenvironment Models Immunological Cancer Cell Biology Endoplasmic Reticulum Stress medicine.disease Cell biology Oxidative Stress 030104 developmental biology Cancer cell Unfolded protein response Molecular Medicine Immunogenic cell death Neuroscience Oxidative stress DNA Damage Signal Transduction |
| Zdroj: | Cellular and Molecular Life Sciences. 75:225-240 |
| ISSN: | 1420-9071 1420-682X |
| DOI: | 10.1007/s00018-017-2597-7 |
| Popis: | The purpose of this review is to explore immune-mediated mechanisms of stress surveillance in cancer, with particular emphasis on the idea that all cancers have classical hallmarks (Hanahan and Weinberg in Cell 100:57-70, 67; Cell 144:646-674, 68) that could be interrelated. We postulate that hallmarks of cancer associated with cellular stress pathways (Luo et al. in Cell 136:823-837, 101) including oxidative stress, proteotoxic stress, mitotic stress, DNA damage, and metabolic stress could define and modulate the inflammatory component of cancer. As such, the overarching goal of this review is to define the types of cellular stress that cancer cells undergo, and then to explore mechanisms by which immune cells recognize, respond to, and are affected by each stress response. |
| Databáze: | OpenAIRE |
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