Haemostasis disorders caused by envenomation by Cerastes cerastes and Macrovipera mauritanica vipers
| Autor: | Noreddine Ghalim, Lotfi Boussadda, Bouchra Makran, Mustapha Lkhider, Laila Fahmi |
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| Rok vydání: | 2016 |
| Předmět: |
Blood Platelets
0301 basic medicine medicine.medical_specialty Erythrocytes Time Factors Physiology Viper Venoms Hematocrit Toxicology Monocytes Hemoglobins 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Leukocytes medicine Animals Lymphocytes Envenomation Mean corpuscular volume Hemostasis biology medicine.diagnostic_test Mean corpuscular hemoglobin concentration Proteolytic enzymes Fibrinogen Cerastes cerastes biology.organism_classification Surgery 030104 developmental biology Prothrombin Time Rabbits Macrovipera mauritanica |
| Zdroj: | Toxicon. 116:43-48 |
| ISSN: | 0041-0101 |
| DOI: | 10.1016/j.toxicon.2015.12.012 |
| Popis: | Viper venoms are a real source of proteolytic enzymes causing clotting, bleeding, edema, necrosis, hemorrhage, pain at the bite site and systemic changes. This study was conducted to evaluate the changes induced in hematological and haemostatic parameters in rabbits after 1, 3, 6 and 24 h post-venom of subcutaneously administration of a sublethal dose of Cerastes cerastes and Macrovipera mauritanica venoms. Our results indicated that most hematological and haemostatic parameters showed significant changes 3 and 6 h after envenomation. The hemoglobin, hematocrit, red blood cells, platelets and prothrombin time were reduced significantly 3 h after envenomation. A very significant increase in the levels of white blood cells, lymphocytes, monocytes, activated thromboplastin time and fibrinogen were recorded 6 h following envenomation. However, no significant difference was found for the mean corpuscular volume, corpuscular hemoglobin content and mean corpuscular hemoglobin concentration throughout the whole duration of the experiment. These results suggest that severe hematological and haemostatic changes may be initiated during the early stages of envenomation leading to local and systemic hemorrhages and coagulopathies which are the main cause of death in case of vipers envenomation. |
| Databáze: | OpenAIRE |
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