Detection of fine modifications in bulk corneal grafts based on backscattered light quantification

Autor: Carole Gard, Silvia Soare, Louis Hoffart, Gaëlle Georges, M. Gonzalvez, Laure Siozade Lamoine, Camille Guerin, Gaëlle Ho Wang Yin, Marion Gil, Carole Deumie
Přispěvatelé: Institut FRESNEL (FRESNEL), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Aix-Marseille Université - Faculté de médecine (AMU MED), Aix Marseille Université (AMU), DiMABio (DiMABio), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Ophtalmologie [Hôpital de la Timone - APMH], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Horus Pharma, Hôpital de la Timone [CHU - APHM] (TIMONE), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Materials science
[PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]
Corneal graft
02 engineering and technology
01 natural sciences
Light scattering
010309 optics
Optics
Cornea
cornea
0103 physical sciences
sensitivity threshold
medicine
Specular reflection
Electrical and Electronic Engineering
Physical and Theoretical Chemistry
[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Scattering
business.industry
021001 nanoscience & nanotechnology
Atomic and Molecular Physics
and Optics
eye diseases
Electronic
Optical and Magnetic Materials
Highly sensitive
medicine.anatomical_structure
[SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic
backscattered light
sense organs
0210 nano-technology
business
Beam (structure)
diagnostic tool
Zdroj: Optics Communications
Optics Communications, Elsevier, 2019, 434, pp.246-252. ⟨10.1016/j.optcom.2018.11.006⟩
Optics Communications, 2019, 434, pp.246-252. ⟨10.1016/j.optcom.2018.11.006⟩
ISSN: 0030-4018
Popis: International audience; A very sensitive technique for quantifying corneal backscattered light which measures the angle-resolved light scattering throughout the reflected space is proposed. Its efficiency to detect different scattering states is compared to that of a technique currently used in hospitals: the Pentacam ®. This technique, based on analyzing the backscattered light close to the specular beam, is less sensitive and it is demonstrate first on agar-agar samples, for which the level of scattering is controlled. In a second time, both techniques are applied on corneal grafts and the first result is confirmed: the Pentacam ® detects an edema after the corneal graft has swollen by hundreds of micrometers; the proposed technique detects the change in scattering before the cornea start to swells. Since the scattering measurements are performed in the reflected space, this highly sensitive method could be applied to in-vivo analysis.
Databáze: OpenAIRE
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