Feline Foamy Virus Infection: Characterization of Experimental Infection and Prevalence of Natural Infection in Domestic Cats with and without Chronic Kidney Disease
Autor: | Sue VandeWoude, Matteo Bordicchia, Jessica M Quimby, Xin Zheng, Julia A. Beatty, Craig Miller, Martin Löchelt, Roderick B. Gagne, Ryan M. Troyer, Carmen Ledesma-Feliciano, Rachel E. Cianciolo, Nicholas G. Dannemiller |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
medicine.medical_specialty foamy virus kidney chronic renal disease 040301 veterinary sciences Urinary system lcsh:QR1-502 Cat Diseases Peripheral blood mononuclear cell lcsh:Microbiology Article Immunophenotyping 0403 veterinary science 03 medical and health sciences Virology medicine Prevalence Animals Renal Insufficiency Chronic Tropism Kidney CATS cats 04 agricultural and veterinary sciences Viral Load spumavirus medicine.disease infection 3. Good health retrovirus Viral Tropism 030104 developmental biology Infectious Diseases medicine.anatomical_structure Immunology Tissue tropism Leukocytes Mononuclear Histopathology Biomarkers chronic kidney disease Kidney disease Retroviridae Infections |
Zdroj: | Viruses Viruses, Vol 11, Iss 7, p 662 (2019) Volume 11 Issue 7 |
ISSN: | 1999-4915 |
Popis: | Foamy viruses (FVs) are globally prevalent retroviruses that establish apparently apathogenic lifelong infections. Feline FV (FFV) has been isolated from domestic cats with concurrent diseases, including urinary syndromes. We experimentally infected five cats with FFV to study viral kinetics and tropism, peripheral blood mononuclear cell (PBMC) phenotype, urinary parameters, and histopathology. A persistent infection of primarily lymphoid tropism was detected with no evidence of immunological or hematologic perturbations. One cat with a significant negative correlation between lymphocytes and PBMC proviral load displayed an expanded FFV tissue tropism. Significantly increased blood urea nitrogen and ultrastructural kidney changes were noted in all experimentally infected cats, though chemistry parameters were not outside of normal ranges. Histopathological changes were observed in the brain, large intestine, and other tissues. In order to determine if there is an association of FFV with Chronic Kidney Disease, we additionally screened 125 Australian pet cats with and without CKD for FFV infection and found that FFV is highly prevalent in older cats, particularly in males with CKD, though this difference was not statistically significant compared to controls. Acute FFV infection was clinically silent, and while some measures indicated mild changes, there was no overt association of FFV infection with renal disease. |
Databáze: | OpenAIRE |
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