Clearance of Treatment Refractory Adenoviremia via Adenovirus-specific Donor T-Cell Transfer During Aplasia After αβTCR-CD19–Depleted Stem Cell Transplantation

Autor:	Olga Kyrillopoulou, Ortwin Adams, Florian Babor, Britta Maecker-Kolhoff, Matthias Aubin, Roland Meisel, Friedhelm R. Schuster, Michael Schumm, Hiba Fouz, Katharina L. Gössling, Arndt Borkhardt, Peter Lang, Meinolf Siepermann, Britta Eiz-Vesper
Rok vydání:	2018
Předmět:	Male 0301 basic medicine Microbiology (medical) T-Lymphocytes T cell medicine.medical_treatment Antigens CD19 030106 microbiology Hematopoietic stem cell transplantation CD19 Adenovirus Infections Human 03 medical and health sciences Fatal Outcome 0302 clinical medicine hemic and lymphatic diseases medicine Humans Viremia 030212 general & internal medicine Transfer technique Child Acute leukemia biology business.industry Hematopoietic Stem Cell Transplantation Aplasia Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Combined Modality Therapy Transplantation Infectious Diseases medicine.anatomical_structure biology.protein Cancer research Stem cell business
Zdroj:	Clinical Infectious Diseases. 68:1406-1409
ISSN:	1537-6591 1058-4838
DOI:	10.1093/cid/ciy820
Popis:	Here, we report the case of severe adenoviremia in a 7-year-old boy with highly-resistant, acute leukemia. A combined approach of αβTCR-CD19-depleted stem cell transplantation, enabling immunosuppression-free post-transplant care, and early transfer of adenovirus-specific donor T cells during aplasia resulted in rapid and complete clearance of the treatment-refractory adenoviremia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85703b3604b9b2c287352989f5541b95 https://doi.org/10.1093/cid/ciy820 Zobrazit plný text záznamu