Therapeutic Effect of Glucosamine on an Atopic Dermatitis Animal Model
| Autor: | Ji Won Byun, Young Hyo Kim, Jeonghyun Shin, Hee Seong Yoon, Gwang Seong Choi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Dermatology Immunoglobulin E Group A Anti-allergic agents 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Glucosamine Internal medicine Medicine Allergy and immunology Saline Atopic dermatitis biology business.industry Therapeutic effect Interleukin medicine.disease carbohydrates (lipids) Cytokine Endocrinology chemistry 030220 oncology & carcinogenesis biology.protein lipids (amino acids peptides and proteins) Original Article business |
| Zdroj: | Annals of Dermatology |
| ISSN: | 2005-3894 1013-9087 |
| Popis: | Background Recent studies have reported that glucosamine (GlcN) showed therapeutic effects in allergic diseases such as asthma and rhinitis, and its mechanisms include the suppression of T helper type 2 immune responses and the nuclear factor-κB pathway. Objective We aimed to investigate the effect of GlcN on atopic dermatitis (AD) in an animal model. Methods Twenty-five BALB/c mice were divided into five groups (groups A~E). Group A was the phosphate-buffered saline (PBS)-treated group without AD induction. Group B was the PBS control group with AD induction. Groups C to E were the AD induction groups, which were treated with three different doses of GlcN (10 mg, 20 mg, and 40 mg, respectively). Histopathological examination was performed after GlcN administration. Interleukin (IL)-4, IL-13, and IL-17 cytokine levels were measured by enzyme-linked immunosorbent assay using skin biopsy specimens. Serum total immunoglobulin E (IgE) concentrations were measured before and after administration with GlcN or PBS. Results Clinical dermatitis scores decreased with increasing GlcN dose (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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