Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity
| Autor: | Martina Di Maro, Mauro Cozzolino, Martina Chiurazzi, Roberta Clara Orsini, Antonio Colantuoni, Matteo Nicola Dario Di Minno |
|---|---|
| Přispěvatelé: | Chiurazzi, M., Cozzolino, M., Orsini, R. C., Di Maro, M., Di Minno, M. N. D., Colantuoni, A. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
obesity Polygenic Obesity Review Biology Monogenic Obesity Bioinformatics Catalysis Epigenesis Genetic lcsh:Chemistry Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine Risk Factors Genetic variation medicine Humans Genetic Predisposition to Disease Epigenetics Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy Early onset epigenetics Risk Factor polygenic obesity Organic Chemistry Body Weight Epigenetic Genetic Variation Insatiable hunger General Medicine Severe obesity medicine.disease Obesity Computer Science Applications 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 syndromic obesity monogenic obesity 030217 neurology & neurosurgery Human |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 9035, p 9035 (2020) |
| ISSN: | 1422-0067 |
| Popis: | Rare genetic obesity disorders are characterized by mutations of genes strongly involved in the central or peripheral regulation of energy balance. These mutations are effective in causing the early onset of severe obesity and insatiable hunger (hyperphagia), suggesting that the genetic component can contribute to 40–70% of obesity. However, genes’ roles in the processes leading to obesity are still unclear. This review is aimed to summarize the current knowledge of the genetic causes of obesity, especially monogenic obesity, describing the role of epigenetic mechanisms in obesity and metabolic diseases. A comprehensive understanding of the underlying genetic and epigenetic mechanisms, with the metabolic processes they control, will permit adequate management and prevention of obesity. |
| Databáze: | OpenAIRE |
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