Is sildenafil citrate affect endometrial receptivity? An immunohistochemical study
| Autor: | Pelin Coştur Biyiksiz, Birol Vural, Serdar Filiz |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Stromal cell Endocrinology Diabetes and Metabolism medicine.medical_treatment Controlled ovarian hyperstimulation Endometrium Piperazines Sildenafil Citrate chemistry.chemical_compound Random Allocation Endocrinology Ovulation Induction Pregnancy Internal medicine Decidua Medicine Animals Embryo Implantation Sulfones Rats Wistar business.industry Vascular Endothelial Growth Factors Integrin beta3 Obstetrics and Gynecology Decidualization Epithelial Cells Fertility Agents Female Phosphodiesterase 5 Inhibitors Immunohistochemistry Placentation Rats Vascular endothelial growth factor medicine.anatomical_structure chemistry Purines Ovulation induction Female Stromal Cells business Biomarkers |
| Zdroj: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 27(10) |
| ISSN: | 1473-0766 |
| Popis: | The authors aimed to investigate the effect of sildenafil citrate (Sc) on expressions of beta(3) integrin and vascular endothelial growth factor (VEGF), which is taking part in endometrium receptivity in implantation window period in controlled ovarian hyperstimulation (COH) performed rats. In this study, Wistar albino female rats were used and were divided into four groups as control, COH, Sc, and COH + Sc groups. They were sacrificed on the third, fourth, and fifth day of pregnancy, uteruses were resected, and uteri sections were stained with immunohistochemical method and evaluated. beta(3) integrin immunoreactivity was most intensely observed in the endometrial glandular epithelium (GE) and stromal cells in the Sc group on the third day, whereas immunoreactivity was most intensely detected in the luminal epithelium (LE), GE, and stromal cells in the Sc group on the fourth day. VEGF immunoreactivity was most intensely observed in the endometrial LE in the Sc group on the third day, in the Sc and COH + Sc groups on the fourth day, and in the COH + Sc group on the fifth day. Our results indicated that Sc plays a role in both implantation and decidualization by affecting beta(3) integrin and VEGF expressions in implantation window period in rats. |
| Databáze: | OpenAIRE |
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