AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches
| Autor: | Pablo Martín-Vasallo, Ricardo Gutiérrez, Deborah Rotoli, Julio Ávila, Manuel Morales, Lucio Díaz-Flores |
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| Rok vydání: | 2023 |
| Předmět: |
0301 basic medicine
Scaffold protein Histology Angiogenesis Cellular differentiation Reviews Biology Tacrolimus Binding Proteins 03 medical and health sciences 0302 clinical medicine IQGAP1 Glioma medicine Humans Tumor microenvironment Cell Differentiation medicine.disease Cell biology 030104 developmental biology Angiomotins ras GTPase-Activating Proteins 030220 oncology & carcinogenesis Neoplastic Stem Cells Anatomy Stem cell Glioblastoma Reprogramming |
| Zdroj: | J Histochem Cytochem |
| ISSN: | 1551-5044 |
| Popis: | Glioma stem cells (GSCs) live in a continuous process of stemness reprogramming to achieve specific cell commitment within the so-called GSC niches, specifically located in periarteriolar regions. In this review, we analyze the expression levels, cellular and subcellular location, and role of three scaffold proteins (IQGAP1, FKBP51, and AmotL2) in GSC niches. Scaffold proteins contribute to cell differentiation, migration, and angiogenesis in glioblastoma. It could be of diagnostic interest for establishing stages, for therapeutic targets, and for improving glioblastoma prognosis, which is still at the experimental level. |
| Databáze: | OpenAIRE |
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