The effects of reverse monocular deprivation in monkeys II. Electrophysiological and anatomical studies
| Autor: | Morris L. J. Crawford, Ronald S. Harwerth, Earl L. Smith, J. T. de Faber, G K von Noorden |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Monocular genetic structures Histocytochemistry General Neuroscience Geniculate Bodies Lateral geniculate nucleus Macaca mulatta Electric Stimulation Functional Laterality eye diseases Ocular dominance Electron Transport Complex IV Monocular deprivation Electrophysiology Geniculate Animals Evoked Potentials Visual Macaca Visual Pathways Psychology Neuroscience Ocular dominance column Binocular neurons Visual Cortex |
| Zdroj: | Experimental Brain Research. 74:338-347 |
| ISSN: | 1432-1106 0014-4819 |
| DOI: | 10.1007/bf00248867 |
| Popis: | Monkeys had one eye closed at about 30 days of age for 14, 30, 60, or 90 days, then opened, and the fellow eye closed for another 120 days. The animals then had at least 10 months of binocular visual experience before extensive behavioral training and testing were carried out. In terminal experiments concluded more than 18 months later, microelectrode investigations of the striate cortex demonstrated that there was almost a complete absence of binocular neurons in all animals. The initially deprived eyes (IDEs) dominated the majority of cortical neurons, even when soma size measurements of lateral geniculate neurons indicated that the LGN cells driven by the IDE had not regained their normal size. The monkeys which had significant interocular differences in spatial vision also exhibited abnormalities in the distribution of the metabolic enzyme, cytochrome oxidase (CO), within the striate cortex. These results demonstrate that many of the severe alterations in cortical physiology and eye dominance produced by early monocular form deprivation can be reversed, with recovery of normal cortical function, via the reverse-deprivation procedure. |
| Databáze: | OpenAIRE |
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