Effects of sodium hyaluronate on tympanic membrane perforations
| Autor: | A. Alonso, T. Casasin, M. P. Rivas Lacarte |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Tympanic Membrane Adolescent medicine.medical_treatment Administration Topical Sodium hyaluronate 030204 cardiovascular system & hematology Placebo Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Myringoplasty Hyaluronic acid medicine Humans Hyaluronic Acid Child Ear Diseases Tympanic Membrane Perforation Chemotherapy business.industry Biochemistry (medical) Tympan Cell Biology General Medicine Middle Aged Middle Ear Ventilation Surgery Otitis Media Membrane chemistry 030220 oncology & carcinogenesis Female business Wound healing |
| Zdroj: | The Journal of international medical research. 20(4) |
| ISSN: | 0300-0605 |
| Popis: | The effects of topically applied 1% sodium hyaluronate as an alternative treatment to surgery for tympanic membrane perforations was studied. In an open study, the inclusion criteria were increased by accepting patients previously treated by surgery or with placebo and, compared with a previous study, the frequency at which sodium hyaluronate was applied was reduced. Reduction in the size of the perforation was detected in 12/16 (75.0%) patients, six (37.5%) of whom showed complete tympanic healing, and in the remaining four (25.0%) there was no healing. The average percentage reduction in the perforation area was 80.5%. The two factors altered in this trial, i.e. inclusion criteria and frequency of administration of treatment, had little influence on the degree of membrane healing. |
| Databáze: | OpenAIRE |
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