Analysis of circulating microRNAs during adjuvant chemotherapy in patients with luminal A breast cancer

Autor:	Fatma Aydogan, Ugur Gezer, Ebru Esin Yoruker, Nejat Dalay, Pinar Saip
Rok vydání:	2015
Předmět:	Cancer Research Oncogene business.industry Cancer Articles Bioinformatics medicine.disease Molecular medicine Circulating MicroRNA Real-time polymerase chain reaction Breast cancer Oncology microRNA Cancer research Medicine Epigenetics business
Zdroj:	Molecular and Clinical Oncology. 3:954-958
ISSN:	2049-9469 2049-9450
Popis:	Breast cancer is a complex disease displaying different profiles involving genetic as well as epigenetic factors. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression. Recent studies demonstrated that miRNAs may display great potential for the development of novel biomarkers and therapeutic targets. In the present study, the levels of miR-21 and miR-145 were analyzed in the peripheral blood of 52 patients with luminal A breast cancer. miRNA expression was determined in serum samples from matched pre- and post-treatment patients with breast cancer by quantitative polymerase chain reaction. There were no statistically significant differences in miR-145 and miR-21 levels between pre- and post-treatment samples. In addition, the miRNA levels were not found to be associated with the clinical parameters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8561c8509e82254cbed1d62061311df7 https://doi.org/10.3892/mco.2015.567 Zobrazit plný text záznamu