Vasodilator Responses of Coronary Conduit and Resistance Arteries to Continuous Nitroglycerin Infusion in Humans: A Doppler Guide Wire Study
| Autor: | Toshiro Miura, Masafumi Yano, Takashi Fujii, Tetsuya Kawabata, Masunori Matsuzaki, Jutaro Yamada, Takafumi Hiro, Kyounori Yasumoto |
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| Rok vydání: | 2000 |
| Předmět: |
Cardiac Catheterization
Vasodilator Agents medicine.medical_treatment Diastole Blood Pressure In Vitro Techniques Anterior Descending Coronary Artery Electrocardiography Nitroglycerin medicine Humans Infusions Intravenous Cardiac catheterization Pharmacology Dose-Response Relationship Drug medicine.diagnostic_test business.industry Angiography Doppler Effect Blood flow Coronary Vessels Vasodilation Blood pressure medicine.anatomical_structure Anesthesia cardiovascular system Coronary perfusion pressure Vascular resistance Vascular Resistance Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiovascular Pharmacology. 36:764-769 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-200012000-00012 |
| Popis: | To examine the responses of coronary conduit and resistance arteries to the continuous i.v. administration of nitroglycerin in 15 patients with atypical chest pain, we measured coronary blood flow velocity in the left anterior descending coronary artery using a Doppler guide wire and the lumen diameter and cross-sectional area by quantitative coronary angiography. Systolic flow, diastolic flow, total coronary flow, and coronary vascular resistance were calculated. Stepwise increases in dose of nitroglycerin resulted in significant dose-dependent decrease in mean aortic pressure (p < 0.01) and increase in lumen diameter (p < 0.05). After nitroglycerin administration of 0.5 microg/kg/min, systolic flow decreased significantly by 89.9+/-15.7% (p < 0.01), and diastolic flow increased significantly by 74.2+/-37.1% (p < 0.05). Total coronary flow did not change significantly with the various doses of nitroglycerin. However, coronary vascular resistance decreased significantly at concentrations greater than 0.5 microg/kg/min nitroglycerin. Continuous nitroglycerin infusion did not reduce either diastolic or total coronary blood flow despite a significant reduction in coronary perfusion pressure. These results indicate that subendocardial blood flow might be maintained during continuous i.v. infusion of nitroglycerin within the clinical dose range. |
| Databáze: | OpenAIRE |
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