microRNA-184 functions as tumor suppressor in renal cell carcinoma
| Autor: | Jiongxian Ye, Zhimao Jiang, Liangchao Ni, Shangqi Yang, Yongqing Lai, Yaoting Gui, Zhengming Su, Enpu Zhang, Duqun Chen, Zuhu Yu, Yifan Li, Ting Chen |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
renal cell carcinoma
Cancer Research Pathology medicine.medical_specialty microRNA Oncogene Cell growth Cell Cancer Cell migration Articles General Medicine Cell cycle Biology medicine.disease medicine.anatomical_structure miR-184 Immunology and Microbiology (miscellaneous) Renal cell carcinoma medicine Cancer research |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| DOI: | 10.3892/etm.2015.2199 |
| Popis: | microRNAs (miRNAs) are evolutionarily conserved, endogenous, small, noncoding RNA molecules of approximately 22 nucleotides in length that function as post-transcriptional gene regulators. Their aberrant expression may be involved in human diseases, including cancer. Although miRNA-184 (miR-184) has been reported in other tumors, its function in renal cell carcinoma (RCC) is still unknown. The aim of the present study was to investigate the role of miR-184 in RCC. The impacts of miR-184 on cell migration, proliferation and apoptosis were evaluated using migration scratch, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry assay. Our studies revealed that miR-184 mimic significantly inhibits cell migration, suppresses cell proliferation and induces renal cancer cell apoptosis in vitro when compared with the negative control (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|