The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in recurrent major depressive disorder; influence of antidepressant use and depressive state?
| Autor: | Lok, A., Mocking, R. J. T., Assies, W. J., Koeter, M. W. J., Bockting, C. L. H., De Vries, G. J., Visser, I., Derks, E. M., Kayser, M., Schene, A. H., Trauma and Grief, Leerstoel Bockting |
|---|---|
| Přispěvatelé: | Trauma and Grief, Leerstoel Bockting, Adult Psychiatry, Other departments, Clinical Psychology and Experimental Psychopathology, Genetic Identification |
| Rok vydání: | 2014 |
| Předmět: |
Male
Oncology Folate SYMPTOMS Homocysteine Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] chemistry.chemical_compound PLASMA HOMOCYSTEINE LEVELS Methylenetetrahydrofolate Reductase Recurrence Mthfr c677t education.field_of_study biology THERMOLABILE VARIANT FOLATE STATUS U.S. ADULTS ASSOCIATION Middle Aged Antidepressive Agents Pathophysiology Vitamin B 12 Psychiatry and Mental health Clinical Psychology Major depressive disorder Antidepressant Female HEALTH Adult medicine.medical_specialty Population METABOLISM Folic Acid (NADPH2)/genetics Internal medicine medicine Humans education Methylenetetrahydrofolate Reductase (NADPH2) Depressive Disorder Major Polymorphism Genetic Depressive disorder business.industry medicine.disease Carbon Vitamin B 6 Endocrinology Vitamin B6 chemistry VITAMIN-B-12 Case-Control Studies Methylenetetrahydrofolate reductase OLDER WOMEN biology.protein Vitamin b6 business |
| Zdroj: | Journal of affective disorders, 166, 115-123. Elsevier Journal of Affective Disorders, 166, 115-123 Journal of Affective Disorders, 166, 115-123. ELSEVIER SCIENCE BV Journal of Affective Disorders, 166, pp. 115-123 Journal of Affective Disorders, 166, 115-123. Elsevier Journal of Affective Disorders, 166, 115. Elsevier |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/j.jad.2014.04.048 |
| Popis: | Item does not contain fulltext BACKGROUND: An important biological factor suggested in the pathophysiology of (recurrent) Major Depressive Disorder (MDD) concerns a polymorphism in a gene encoding for the MTHFR-enzyme of the one-carbon (1-C)-metabolism. Integratively investigating key 1-C-components (folate, homocysteine, vitamin B6 and B12), including the possible effects of antidepressant medication and depressive state, could provide more insight in the possible association between the MTHFR-polymorphism and recurrent MDD. METHODS: We compared the MTHFR C677T-polymorphism together with the key 1-C-components in clinically ascertained patients with recurrent MDD (n=137) to age- and gender-matched healthy controls (n=73). RESULTS: First, patients had lower folate (t=2.25; p=.025) as compared to controls; a difference that resolved after correction for demographics (t=1.22; p=.223). Second, patients that were depressed during sampling had lower vitamin B6 (t=-2.070; p=.038) and higher homocysteine (t=2.404; p=.016) compared to those in remission. Finally, current use of antidepressants had no influence on the 1-C-components. CONCLUSIONS: Despite investigation of a specific recurrently depressed patient population, we found no clear associations with the 1-C-cycle, except for higher homocysteine and lower vitamin B6 during the depressed state. This suggests that 1-C-cycle alterations in MDD are state-associated, possibly resulting from high levels of acute (psychological) stress, and may provide a treatment target to reduce cardiovascular risk in this population. 9 p. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect