Respiratory-gated imaging in metabolic evaluation of small solitary pulmonary nodules
| Autor: | Vincent Servois, Slavomir Petras, Xavier Poullias, Marco Alifano, Jean-François Regnard, Karim Farid, Nadine Caillat-Vigneron |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Lung Diseases Male medicine.medical_specialty Lung Neoplasms Standardized uptake value Multimodal Imaging Sensitivity and Specificity Diagnosis Differential Fluorodeoxyglucose F18 medicine Humans Radiology Nuclear Medicine and imaging Four-Dimensional Computed Tomography Aged Aged 80 and over Solitary pulmonary nodule Lung medicine.diagnostic_test business.industry Reproducibility of Results Solitary Pulmonary Nodule Nodule (medicine) General Medicine Middle Aged medicine.disease medicine.anatomical_structure Positron emission tomography Positron-Emission Tomography Large-cell lung carcinoma Adenocarcinoma Female Sarcoma Radiology Radiopharmaceuticals medicine.symptom Tomography X-Ray Computed business |
| Zdroj: | Nuclear Medicine Communications. 36:722-727 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/mnm.0000000000000311 |
| Popis: | OBJECTIVE The aim of the study was to evaluate the effect of 2-((18)F)-fluoro-2-deoxy-D-glucose ((18)F-FDG)-PET/computed tomography (CT) respiratory-gated imaging [four-dimensional (4D)] in the metabolic evaluation of small solitary pulmonary nodules and analyze the cutoff maximum standardized uptake value (SUV(max)) of 2.5 in classifying and distinguishing benign/malignant pulmonary pathologies in 4D studies. MATERIALS AND METHODS Thirty-two patients with pulmonary lesions measuring 2 cm or less were included during their scheduled (18)F-FDG PET/CT examinations. The whole-body PET/CT acquisition (3D) was followed by a chest-centered PET/CT (4D) study synchronized with the respiratory cycle. The SUV(max) percentage difference (%Diff SUV(max)) was calculated. The nodule size, localization, and relationships with histological/cytological findings were studied. RESULTS Fifteen nodules were 10 mm or smaller and 17 were larger than 10 mm [mean size = 12 mm (7-20)]. The mean 3D-SUV(max) was 2.5 (0.7-6.1) and the mean 4D-SUV(max) 3.2 (0.9-7.2) (P < 0.001). The mean %Diff SUV(max) was 38% for all patients (7-90), 45% in subcentimetric (7-90%) and 31% (7-75%) in supracentimetric lesions (P = NS). Histology was obtained in 23/32 (72%) cases and the pathologic benign/malignant ratio was 4/19. Malignancies were diagnosed as lung adenocarcinoma, solitary metastases, large cell lung carcinoma, and sarcoma in 13 (41%), 3 (9%), 2 (6%), and 1 (3%) case, respectively. Malignant lesions showed mean 4D-SUV(max) of 3.8 (1.2-7.2). The cutoff SUV(max) of 2.5 did not classify and distinguish between benign/malignant pulmonary pathologies, neither in 3D nor in 4D studies. CONCLUSION Respiratory gating improves the detectability and metabolic evaluation of solitary pulmonary nodules, mostly those that are subcentimetric. However, as expected, the cutoff SUV(max) of 2.5 does not distinguish between benign/malignant lesions in either 4D or 3D studies. |
| Databáze: | OpenAIRE |
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