Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland
| Autor: | Susan S. Yamada, Henning Birkedal-Hansen, Kenn Holmbeck, Ludmila Szabova |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Aging
medicine.medical_specialty Matrix Metalloproteinases Membrane-Associated Physiology Clinical Biochemistry Mammary gland Mouse Mammary Gland Mammary Neoplasms Animal Biology Matrix metalloproteinase medicine.disease_cause Gene Expression Regulation Enzymologic Extracellular matrix Mice Mammary Glands Animal stomatognathic system Expression pattern Stroma Pregnancy Internal medicine Matrix Metalloproteinase 14 medicine Animals Lactation Gene Expression Profiling Matrix Metalloproteinase 15 Metalloendopeptidases Matrix Metalloproteinase 16 Cell Biology Metallothionein 3 Cell biology medicine.anatomical_structure Endocrinology Mammary Epithelium Health Female Carcinogenesis |
| Zdroj: | Journal of Cellular Physiology. 205:123-132 |
| ISSN: | 1097-4652 0021-9541 |
| DOI: | 10.1002/jcp.20385 |
| Popis: | Both mammary gland development and mammary carcinogenesis involve extensive remodeling of the mammary gland extracellular matrix. The expression of four membrane-type matrix metalloproteinases (MT-MMPs) with matrix remodeling potential in development and tumorigenesis was evaluated by in-situ hybridization on mouse mammary gland sections. MT1-MMP and MT3-MMP were found in the mammary stroma mainly around epithelial structures in both developing and mature mammary gland. In contrast, MT2-MMP was found exclusively in the mammary epithelium. Lactating gland expressed none of the examined MT-MMPs. Mammary gland tumors expressed MT1-MMP, MT2-MMP, and MT3-MMP while MT4-MMP was not expressed in any developmental or cancerous stage analyzed here. Our results suggest that MT1-MMP, MT2-MMP, and MT3-MMP may be involved in remodeling of both the normal and diseased mammary gland either directly or indirectly by activation of other MMPs. Published 2005 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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