IL-4-producing CD8+ T cells may be an immunological hallmark of chronic GVHD
| Autor: | Yonsu Son, Ryuichi Amakawa, Katsuhiro Zen, Kengo Nakamura, Yuji Kishimoto, S. Fukuhara, Michihiko Miyaji, Masashi Takebayashi, Tomoki Ito, Noriaki Matsumoto, K Nakai, Kenichirou Tajima |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Time Factors Adolescent medicine.medical_treatment Graft vs Host Disease Hematopoietic stem cell transplantation CD8-Positive T-Lymphocytes Interferon-gamma Recurrence immune system diseases hemic and lymphatic diseases medicine Humans Transplantation Homologous Cytotoxic T cell Interferon gamma Interleukin 4 Transplantation business.industry Hematopoietic Stem Cell Transplantation Hematology T lymphocyte Middle Aged Flow Cytometry Cytokine Case-Control Studies Chronic Disease Immunology Cytokines Female Interleukin-4 business CD8 medicine.drug |
| Zdroj: | Bone Marrow Transplantation. 36:639-647 |
| ISSN: | 1476-5365 0268-3369 |
| DOI: | 10.1038/sj.bmt.1705107 |
| Popis: | Chronic graft-versus-host disease (cGVHD) occurs in approximately 60-80% of those who survive over 100 days after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the pathophysiology of cGVHD is poorly understood. To gain more insight into the immunological mechanism of cGVHD, we examine cytokine production of peripheral blood T cells from 19 patients in the chronic phase of allo-HSCT. The percentage of IFN-gamma-producing CD8(+) T cells among CD8(+) T cells was significantly higher in patients with or without cGVHD than in normal control subjects (P |
| Databáze: | OpenAIRE |
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