Ultrasonic Actuation of a Fine-Needle Improves Biopsy Yield
| Autor: | Emanuele Perra, Eetu Lampsijärvi, Gonçalo Barreto, Muhammad Arif, Tuomas Puranen, Edward Hæggström, Kenneth P. H. Pritzker, Heikki J. Nieminen |
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| Přispěvatelé: | Department of Physics, HUS Internal Medicine and Rehabilitation, TRIMM - Translational Immunology Research Program, Department of Neuroscience and Biomedical Engineering, University of Helsinki, University of Toronto, Aalto-yliopisto, Aalto University |
| Rok vydání: | 2020 |
| Předmět: |
Science
Biopsy Fine-Needle 116 Chemical sciences FOS: Physical sciences RADIATION FORCE 114 Physical sciences Article Drug Delivery Systems Animals Humans Minimally Invasive Surgical Procedures Ultrasonics DRUG COLLAPSE Ultrasonography Interventional Phantoms Imaging Gene Transfer Techniques Acoustics Physics - Medical Physics SIZE Surgery Computer-Assisted DEFLECTION Needles TISSUE 3121 General medicine internal medicine and other clinical medicine Medicine Cattle Medical Physics (physics.med-ph) Biomedical engineering |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021) |
| DOI: | 10.48550/arxiv.2006.16604 |
| Popis: | Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip,i.e.the lancet. In this study, we demonstrate how nonlinear ultrasonics (NLU) extends the functionality of the medical needle far beyond its present capability. The NLU actions were found to be localized to the proximity of the needle tip, the SonoLancet, but the effects extend several millimeters from the physical needle boundary. The observed nonlinear phenomena, transient cavitation, fluid streams, translation of micro- and nanoparticles and atomization, were quantitatively characterized. In the fine-needle biopsy application, the SonoLancet contributed to obtaining tissue cores with increase in tissue yield by 3-6x in different tissue types compared to conventional needle biopsy technique using the same 21G needle. In conclusion, the SonoLancet could be of interest to several other medical applications, including drug or gene delivery, cell modulation, and minimally invasive surgical procedures. Comment: Revised manuscript, 19 pages, 7 figures |
| Databáze: | OpenAIRE |
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