Development of pyogenic granuloma with strong vascular endothelial growth factor receptor-2 expression during ramucirumab treatment
| Autor: | Mikage Takabatake, Shingo Kamoshida, Yoichiro Hamamoto, Tatsuya Ibe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty skin medicine.medical_treatment Antineoplastic Agents chemotherapy Antibodies Monoclonal Humanized Ramucirumab 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Humans Granuloma Pyogenic Lung cancer Chemotherapy Pyogenic granuloma business.industry Mucous membrane Kinase insert domain receptor General Medicine Middle Aged medicine.disease Vascular Endothelial Growth Factor Receptor-2 lung cancer (oncology) Angiogenesis inhibitor dermatology medicine.anatomical_structure Docetaxel 030220 oncology & carcinogenesis Female business medicine.drug Findings That Shed New Light on the Possible Pathogenesis of a Disease or an Adverse Effect |
| Zdroj: | BMJ Case Reports |
| ISSN: | 1757-790X |
| Popis: | The angiogenesis inhibitor ramucirumab (IMC-1121B) is a fully humanised IgG1 monoclonal antibody targeting the extracellular domain of vascular endothelial growth factor receptor 2. Ramucirumab has been approved as a second-line treatment for lung cancer. Pyogenic granuloma is an acquired, benign vascular tumour of the skin or mucous membrane. We encountered a patient with pyogenic granuloma who was treated with ramucirumab. The patient was a 48-year-old Japanese woman with advanced lung cancer who had been heavily pretreated using several lines of chemotherapy. Ramucirumab was administered as the fifth-line treatment with docetaxel. After 10 days, a painless rice-coloured or pink papule appeared on her finger. One month later, it increased in size to 20 mm. We examined the pathological condition by immunostaining using the resected specimen diagnosed as pyogenic granuloma. Paradoxically, this vascular tumour arose during the administration of an angiogenesis inhibitor. |
| Databáze: | OpenAIRE |
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