Single-session magnetic resonance coronary angiography and myocardial perfusion imaging using the new blood pool compound B-22956 (gadocoletic acid): initial experience in a porcine model of coronary artery disease
| Autor: | Orlando P. Simonetti, Friedrich M. Cavagna, Jie Zheng, Gerhard Laub, Robert J. Gropler, Dana R. Abendschein, Debiao Li, J. Paul Finn, Fabio Maggioni |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Swine Contrast Media Perfusion scanning Coronary Angiography Statistics Nonparametric Coronary artery disease Myocardial perfusion imaging Internal medicine medicine.artery Image Processing Computer-Assisted Organometallic Compounds Medicine Animals Radiology Nuclear Medicine and imaging medicine.diagnostic_test business.industry Coronary Stenosis Magnetic resonance imaging General Medicine medicine.disease Stenosis Disease Models Animal medicine.anatomical_structure Right coronary artery Cardiology business Perfusion Magnetic Resonance Angiography Artery |
| Zdroj: | Investigative radiology. 40(9) |
| ISSN: | 0020-9996 |
| Popis: | The objective of this study was to evaluate a new blood pool contrast agent, B-22956, for detecting myocardial perfusion abnormality and coronary artery stenosis by magnetic resonance imaging (MRI) in 1 setting.Coronary artery atherosclerotic stenoses were created in 6 miniswine. Myocardial first-pass perfusion imaging was performed with a bolus injection of 0.015 mmol/kg B-22956 during pharmacologic stress followed by postcontrast coronary artery imaging after another injection of B-22956/1. The total doses for the 6 pigs were 0.1 mmol/kg (n=3) and 0.15 mmol/kg (n=3). Perfusion upslope maps were analyzed and MR coronary artery images were reviewed by 2 readers.For all 6 pigs, the normalized upslopes of the perfusion curves were 0.83+/-0.12, 0.74+/-0.15, and 0.52+/-0.05 (P0.01 vs. normal) with normal or mild (50% area stenosis), moderate (50% and75%), and severe stenosis (75%), respectively. Mean signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in right coronary artery images improved 90% and 200%, respectively, with a total dose of 0.1 mmol/kg of B-22956. Excellent agreements (kappa=0.82) were achieved for evaluating the grade of stenosis between MR postcontrast coronary artery images and histopathology by 2 reviewers.The MR blood pool contrast agent B-22956 demonstrated the ability for detecting myocardial perfusion abnormalities and coronary artery stenosis in 1 setting. |
| Databáze: | OpenAIRE |
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