Selective and long-term learning impairment following neonatal hypoxic-ischemic brain insult in rats
| Autor: | Yi X. Xia, Michihiro Fujiwara, Tetsuya Yoshikawa, Katsunori Iwasaki, Tsuyomu Ikenoue, Tomoaki Ikeda, Kenichi Mishima |
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| Rok vydání: | 2001 |
| Předmět: |
Male
media_common.quotation_subject Models Neurological Ischemia Brain damage Water maze Choice Behavior Developmental psychology Behavioral Neuroscience Memory medicine Memory impairment Animals Rats Wistar Maze Learning media_common Working memory Learning Disabilities Memoria Cognition medicine.disease Rats Anesthesia Hypoxia-Ischemia Brain Female medicine.symptom Psychology Vigilance (psychology) |
| Zdroj: | Behavioural brain research. 118(1) |
| ISSN: | 0166-4328 |
| Popis: | We examined four different learning and memory tasks in rats which had been subjected to left carotid artery ligation followed by 2 h hypoxia (8% oxygen) when they were 7 days old. The examination began on the 4th week after insult and continued to 18 weeks post-insult. Compared with the control group, the hypoxic-ischemic group showed significant learning impairments in choice reaction time tasks relating to the attention process, and in plus-maze tasks and water maze tasks which examine long-term reference memory. In eight-arm radial maze tasks representing both short-term working memory and long-term reference memory, inferiority of the hypoxic-ischemic group was transient. Results of the sensorimotor test were normal in the hypoxic-ischemic group although slight flexion and twisting in the right forelimb was observed in 30% of the hypoxic-ischemic group when suspended by the tail. These abnormalities did not affect the results of learning tests. Findings of the study indicate that left-side brain damage produced by hypoxia-ischemia at 7 days of age resulted in selective and long-lasting learning and memory impairment. |
| Databáze: | OpenAIRE |
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