Time Course of Autonomic Symptoms in Postural Orthostatic Tachycardia Syndrome (POTS) Patients: Two-Year Follow-Up Results
| Autor: | Beatrice Cairo, Franca Barbic, Dana Shiffer, Caterina Barberi, Elena Castelnuovo, Antonio Roberto Zamunér, Raffaello Furlan, Maura Minonzio, Roberto Fornerone, Franca Dipaola |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Visual analogue scale Health Toxicology and Mutagenesis Orthostatic intolerance lcsh:Medicine 030204 cardiovascular system & hematology Autonomic Nervous System Article orthostatic hypotension Cohort Studies 03 medical and health sciences Postural Orthostatic Tachycardia Syndrome Young Adult 0302 clinical medicine Quality of life medicine Humans business.industry lcsh:R Public Health Environmental and Occupational Health technology industry and agriculture Repeated measures design food and beverages Middle Aged medicine.disease POTS working syncope Cohort Physical therapy Quality of Life Autonomic symptoms Female Analysis of variance business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 17 Issue 16 International Journal of Environmental Research and Public Health, Vol 17, Iss 5872, p 5872 (2020) |
| ISSN: | 1660-4601 1661-7827 |
| Popis: | Postural orthostatic tachycardia syndrome (POTS) is a multifactorial condition capable of chronically reducing the quality of life and the work ability of patients. The study aim was to assess the burden of autonomic symptoms in a cohort of POTS patients over 2 years. Patients&rsquo clinical profiles were assessed by the 31-item Composite Autonomic Symptom Score questionnaire (COMPASS 31) and a visual analog scale (VAS). One-way ANOVA for repeated measures followed by Dunnett&rsquo s post-hoc test were used to compare symptoms at baseline and at 1 and 2 years. Out of 42 enrolled patients, 25 had a 1-year follow-up and 12 had a 2-year follow-up. At baseline, the reported burden of autonomic symptoms was high (overall COMPASS 31 = 49.9 ± 14.3 /100). Main complaints were related to orthostatic intolerance according to both COMPASS 31 and VAS. Fourteen patients were rendered inactive because of symptoms. At 1-year follow-up, a statistically significant improvement in pupillomotor function and overall score was detected by the COMPASS 31. These findings were confirmed at 2 years, together with a significant reduction in quality of life impairment, assessed by VAS. However, these improvements did not change patients&rsquo occupational status. Awareness of POTS diagnosis, patient monitoring, and tailored therapies can help to improve patients&rsquo condition. |
| Databáze: | OpenAIRE |
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