Inhalation exposure to chloramine T induces DNA damage and inflammation in lung of Sprague-Dawley rats
| Autor: | Byung lL Yoon, Mimi Lee, Byung Woo Lee, Ilseob Shim, Pilje Kim, Gyun Baek Seo, Kyunghee Choi, Jung-Taek Kwon, Hyun-Mi Kim, Eunha Oh, Donggeun Sul |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Antioxidant No-observed-adverse-effect level Time Factors medicine.medical_treatment Pharmacology Toxicology Rats Sprague-Dawley Tosyl Compounds chemistry.chemical_compound Glutathione Peroxidase GPX1 Administration Inhalation medicine Animals Lung Inhalation exposure Homeodomain Proteins Glutathione Peroxidase Inhalation Exposure No-Observed-Adverse-Effect Level Inhalation Dose-Response Relationship Drug Superoxide Dismutase Chloramines Pneumonia Rats Comet assay Dose–response relationship chemistry Anesthesia Chloramine-T Toxicity Female DNA Damage Disinfectants |
| Zdroj: | The Journal of toxicological sciences. 38(6) |
| ISSN: | 1880-3989 |
| Popis: | Chloramine T has been widely used as a disinfectant in many areas such as kitchens, laboratories and hospitals. It has been also used as a biocide in air fresheners and deodorants which are consumer products; however, little is known about its toxic effects by inhalation route. This study was performed to identify the subacute inhalation toxicity of chloramine T under whole-body inhalation exposure conditions. Male and female groups of rats were exposed to chloramine T at concentrations of 0.2, 0.9 and 4.0 mg/m³ for 6 hr/day, 5 days/week during 4 weeks. After 28-day repeated inhalation of chloramine T, there were dose-dependently significant DNA damage in the rat tissues evaluated and inflammation was histopathologically noted around the terminal airways of the lung in both genders. As a result of the expression of three types of antioxidant enzymes (SOD-2, GPx-1, PRX-1) in rat's lung after exposure, there was no significant change of all antioxidant enzymes in the male and female rats. The results showed that no observed adverse effect level (NOAEL) was 0.2 mg/m³ in male rats and 0.9 mg/m³ in female rats under the present experimental condition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|