Association of ECG parameters with late gadolinium enhancement and outcome in patients with clinical suspicion of acute or subacute myocarditis referred for CMR imaging
| Autor: | Stephan Windecker, Tobias Reichlin, Ayaz Aghayev, Kyoichi Kaneko, Michael L. Steigner, Adrian Thomas Huber, Maximilian Marggraf, Anselm W. Stark, Raymond Y. Kwong, Christoph Gräni, Ron Blankstein, Kady Fischer, Dominik P. Guensch |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Contrast Media Gadolinium Cardiovascular Medicine 030204 cardiovascular system & hematology Pathology and Laboratory Medicine Diagnostic Radiology 030218 nuclear medicine & medical imaging Electrocardiography 0302 clinical medicine Medicine and Health Sciences Edema Cumulative incidence Cardiovascular Imaging Multidisciplinary Ejection fraction medicine.diagnostic_test Radiology and Imaging Middle Aged Prognosis Magnetic Resonance Imaging 3. Good health Myocarditis Chemistry Bioassays and Physiological Analysis Cardiovascular Diseases Physical Sciences cardiovascular system Cardiology Medicine Female Research Article Chemical Elements Adult medicine.medical_specialty Imaging Techniques Science 610 Medicine & health Research and Analysis Methods Risk Assessment 03 medical and health sciences QRS complex Signs and Symptoms Diagnostic Medicine Internal medicine medicine Humans cardiovascular diseases Retrospective Studies business.industry Electrophysiological Techniques Biology and Life Sciences Magnetic resonance imaging medicine.disease Fibrosis Heart failure Cardiac Electrophysiology business Mace Developmental Biology Ejection Fraction |
| Zdroj: | PLoS ONE PLoS ONE, Vol 15, Iss 1, p e0227134 (2020) Fischer, Kady; Marggraf, Maximilian; Stark, Anselm W; Kaneko, Kyoichi; Aghayev, Ayaz; Günsch, Dominik P; Huber, Adrian T.; Steigner, Michael; Blankstein, Ron; Reichlin, Tobias Roman; Windecker, Stephan; Kwong, Raymond Y; Gräni, Christoph (2020). Association of ECG parameters with late gadolinium enhancement and outcome in patients with clinical suspicion of acute or subacute myocarditis referred for CMR imaging. PLoS ONE, 15(1), e0227134. Public Library of Science 10.1371/journal.pone.0227134 |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND Risk stratification of myocarditis is challenging due to variable clinical presentations. Cardiovascular magnetic resonance (CMR) is the primary non-invasive imaging modality to investigate myocarditis while electrocardiograms (ECG) are routinely included in the clinical work-up. The association of ECG parameters with CMR tissue characterisation and their prognostic value were investigated in patients with clinically suspected myocarditis. METHODS AND RESULTS Consecutive patients with suspected myocarditis who underwent CMR and ECG were analysed. Major adverse cardiovascular event (MACE) included all-cause death, hospitalisation for heart failure, heart transplantation, documented sustained ventricular arrhythmia, or recurrent myocarditis. A total of 587 patients were followed for a median of 3.9 years. A wide QRS-T angle, low voltage and fragmented QRS were significantly associated with late gadolinium enhancement. Further, a wide QRS-T angle, low voltage and prolonged QTc duration were associated with MACE in the univariable analysis. In a multivariable model, late gadolinium enhancement (HR: 1.90, 95%CI: 1.17-3.10; p = 0.010) and the ECG parameters of a low QRS voltage (HR: 1.86, 95%CI: 1.01-3.42; p = 0.046) and QRS-T-angle (HR: 1.01, 95%CI: 1.00-1.01; p = 0.029) remained independently associated with outcome. The cumulative incidence of MACE was incrementally higher when findings of both CMR and ECG were abnormal (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|