Potentiation of a non-narcotic analgesic, dipyrone, by cholinomimetic drugs

Autor:	Usha G. Kamat, Ratan J. Pradhan, Sheth Uk
Rok vydání:	1972
Předmět:	Atropine Male Nicotine Physostigmine Dextroamphetamine Carbachol Tremorine Analgesic Pharmacology Methylamines Mice Animals Medicine Sympathomimetics business.industry Pilocarpine Drug Synergism Neostigmine Cholinergic Female Sulfonic Acids business Drug Antagonism Antipyrine medicine.drug
Zdroj:	Psychopharmacologia. 23:180-186
ISSN:	1432-2072 0033-3158
Popis:	Dipyrone analgesia in mice was potentiated by physostigmine, neostigmine and pilocarpine. This potentiation was antagonized by atropine sulfate and atropine methyl nitrate. Tremorine and dextroamphetamine which implicate brain monoamines in their analgesic effects, were inactive, as were carbachol and nicotine. Hydroxyzine did not potentiate dipyrone analgesia, ruling out a CNS depressant component in dipyrone potentiation. It was concluded that dipyrone which has central analgesic (Ruhnau, 1951) and parasympathomimetic effects (Lindner, 1956) is specifically potentiated by cholinergic drugs. Such potentiation of a non-narcotic analgesic by cholinergic agents argues against a specific involvement of cholinergic receptors in narcotics analgesia (and/or other narcotics' actions) and may indicate a cholinergic involvement in pain mechanisms and/or central analgesic effects without specific reference to narcotics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854f4f86eebeae502e05f3ebec93d08e https://doi.org/10.1007/bf00401193 Zobrazit plný text záznamu Full text from SpringerLink