Tranexamic acid reduces postoperative bleeding in off-pump coronary artery bypass grafting

Autor:	Lianxiang Zhang, Dazhong Jiang, Minxin Wei, Kaitao Jian, Matti Tarkka, Zhi-gang Guo, Lianqun Wang
Rok vydání:	2006
Předmět:	Male Coronary artery surgery medicine.medical_specialty medicine.medical_treatment Coronary Artery Bypass Off-Pump Postoperative Hemorrhage Chemoprevention Perioperative Care Angina Pectoris law.invention Fibrin Fibrinogen Degradation Products Platelet Adhesiveness Blood loss law Fibrinolysis medicine Cardiopulmonary bypass Humans Prospective cohort study Aged Fibrinopeptide A Off-pump coronary artery bypass Postoperative Care business.industry Middle Aged Antifibrinolytic Agents Surgery Treatment Outcome Tranexamic Acid Anesthesia Perioperative care Female Cardiology and Cardiovascular Medicine business Tranexamic acid medicine.drug
Zdroj:	Scandinavian Cardiovascular Journal. 40:105-109
ISSN:	1651-2006 1401-7431
Popis:	Tranexamic acid (TA) reduces blood loss in coronary artery surgery with cardiopulmonary bypass. The present prospective study was designed to investigate its hemostatic effect in off-pump coronary artery bypass (OPCAB).Seventy-six patients undergoing elective OPCAB were randomized into two groups, received TA (0.75 g loading dose before surgery and 250 mg/h during surgery, gross dose: 1.5 g, n=36) and saline solution (control, n=40), respectively. Perioperative blood samples were collected. Hematochemical parameters including platelet adhesion rate, D-dimer and fibrinopeptide-A (FPA) were analysis. Volume of blood loss, blood transfusion and other clinical data were recorded throughout the perioperative period.Cumulative blood loss was significantly reduced in the TA group as compared to the controls postoperatively (6 hrs (median [25th-75th]): TA: 200.0 [140.0-230.0] ml,225.0 [200.0-347.5.0] ml, p=0.009; 24 hrs: TA: 440.0 [270.0-605.0] ml,655.0 [500.0-920.0] ml, p0.001). Number of patients received blood transfusion in each group was similar. Levels of D-dimer rose significantly after surgery, and were significantly lower in the TA group than that in controls. Platelet adhesion rate and FPA levels remained at baseline levels after the operation in two groups. Early clinical outcomes were similar between groups.The results indicated that tranexamic acid limits fibrinolysis and reduces blood loss after off-pump coronary artery bypass surgery.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854e931a8d72e89af879ed0320467995 https://doi.org/10.1080/14017430500519864 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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