EXTRACORPOREAL IRRADIATION OF THE BLOOD AS IMMUNOSUPPRESSIVE TREATMENT IN RENAL TRANSPLANTATION
| Autor: | Søren Freiesleben Sørensen, Bjarne Bahr, Vagn Andersen, Eva Weeke |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Extracorporeal Circulation medicine.medical_specialty Lymphocyte Urology Renal function Azathioprine Extracorporeal Renal Dialysis Transplantation Immunology Prednisone Preoperative Care Internal Medicine medicine Humans Lymphocytes Kidney transplantation Uremia business.industry Extracorporeal circulation Middle Aged medicine.disease Kidney Transplantation Surgery Radiation Effects Transplantation Blood medicine.anatomical_structure Female business medicine.drug |
| Zdroj: | Acta Medica Scandinavica. 187:183-188 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1970.tb02929.x |
| Popis: | Seventeen consecutive patients in terminal uraemia were treated with extracorporeal irradiation of the blood (ECI) as pretransplantation immunosuppressive therapy. Eleven patients have received a kidney transplant, and eight of these were treated with ECI after the transplantation too. The transit dose employed was 280–610 rads, the average total dose 54,600 rads. In all patients the lymphocyte concentration in the blood decreased during ECI, on the average to 20% of pretreatment values, or to 290 ± 110/μl. No correlation was observed between transit dose and decrease in lymphocyte concentration. After ECI the lymphocyte counts have remained below 50% of pretreatment values in all patients including those who were not transplanted and therefore did not receive other immunosuppressive therapy (maximum 14 months of observation). Ten patients received a kidney transplant from a related living donor (2 Al match, 6 C match, 2 D match) and one a necrokidney (D or E match). All transplanted patients were treated with azathioprine and prednisone; the dosages employed were relatively small. Two rejection episodes have occurred, both slight and reversible, and renal function is now, 1 to 12 months after transplantation, normal in all. |
| Databáze: | OpenAIRE |
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