Combination adjuvants: the next generation of adjuvants?

Autor:	Volker Gerdts, Nelson F. Eng, Lorne A. Babiuk, Andrew A. Potter, Gaël Auray, Srinivas Garlapati, Sylvia van Drunen Littel-van den Hurk, George Mutwiri
Rok vydání:	2011
Předmět:	Pharmacology Vaccines business.industry medicine.medical_treatment Immunology Computational biology Biopharmaceutics Drug Combinations Immune system Adjuvants Immunologic Drug Discovery medicine Humans Molecular Medicine business Adjuvant Selection (genetic algorithm)
Zdroj:	Expert Review of Vaccines. 10:95-107
ISSN:	1744-8395 1476-0584
Popis:	Adjuvants are critical components of many vaccines. The majority of existing vaccines contain a single adjuvant. Owing to their inherent limitations, no single adjuvant is capable of inducing all the protective immune responses required in the many different vaccines. Consequently, investigators are exploring the potential of using formulations with multiple adjuvants in a vaccine. An emerging paradigm is that careful selection of adjuvant combinations can result in complementary and even synergistic enhancement of immune responses to vaccines. This approach is promising and presents tremendous opportunities for vaccinologists to tailor immune responses to specific vaccines. In this article, adjuvant combinations at different stages of development will be reviewed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854886526f52b8dcb5460ecffb3208ef https://doi.org/10.1586/erv.10.154 Zobrazit plný text záznamu