Genes and environment as predisposing factors in autoimmunity: acceleration of spontaneous thyroiditis by dietary iodide in NOD.H2(h4) mice

Autor:	Justin J. King, George Carayanniotis, Panayota Kolypetri, Mani Larijani
Rok vydání:	2015
Předmět:	medicine.medical_treatment Immunology Gene Expression Autoimmunity Nod Disease Environment medicine.disease_cause Thyroglobulin Thyroiditis Autoimmune thyroiditis Mice Mice Inbred NOD T-Lymphocyte Subsets Immunology and Allergy Medicine Animals Humans Autoantibodies Autoimmune disease B-Lymphocytes business.industry Autoantibody Thyroiditis Autoimmune Iodides medicine.disease Disease Models Animal Dietary Supplements Cytokines Gene-Environment Interaction business
Zdroj:	International reviews of immunology. 34(6)
ISSN:	1563-5244
Popis:	In the field of autoimmune thyroiditis, NOD.H2(h4) mice have attracted significant and increasing attention since they not only develop spontaneous disease but they present thyroiditis with accelerated incidence and severity if they ingest iodide through their drinking water. This animal model highlights the interplay between genetic and dietary factors in the triggering of autoimmune disease and offers new opportunities to study immunoregulatory parameters influenced by both genes and environment. Here, we review experimental findings with this mouse model of thyroiditis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854762b102f714b1a7100a00b4a676ba https://pubmed.ncbi.nlm.nih.gov/26287317 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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