Stereoselective Access to Azetidine-Based α-Amino Acids and Applications to Small Peptide Synthesis
| Autor: | Benedikt Nißl, Felix Reiners, Emanuel Joseph, Dorian Didier |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Stereochemistry Carboxylic acid Organic Chemistry Azetidine Stereoisomerism Chemistry Techniques Synthetic Protein engineering 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Amino acid chemistry.chemical_compound chemistry Small peptide Azetidines Stereoselectivity Amino Acids Physical and Theoretical Chemistry Peptides |
| Zdroj: | Organic Letters. 22:8533-8537 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | Non-natural azetidine-based amino acids (Aze) present interesting features in protein engineering. A simple organometallic route toward unsaturated carboxylic acid precursors is presented. Subsequent metal-catalyzed asymmetric reduction allowed for the synthesis of a new library of 2-azetidinylcarboxylic acids, which were finally employed in the formation of small peptide chains. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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