Two-pore channels: going with the flows
| Autor: | Anthony J. Morgan, Lora L. Martucci, Lianne C. Davis, Antony Galione |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Biochemical Society Transactions. 50:1143-1155 |
| ISSN: | 1470-8752 0300-5127 |
| Popis: | In recent years, our understanding of the structure, mechanisms and functions of the endo-lysosomal TPC (two-pore channel) family have grown apace. Gated by the second messengers, NAADP and PI(3,5)P2, TPCs are an integral part of fundamental signal-transduction pathways, but their array and plasticity of cation conductances (Na+, Ca2+, H+) allow them to variously signal electrically, osmotically or chemically. Their relative tissue- and organelle-selective distribution, together with agonist-selective ion permeabilities provides a rich palette from which extracellular stimuli can choose. TPCs are emerging as mediators of immunity, cancer, metabolism, viral infectivity and neurodegeneration as this short review attests. |
| Databáze: | OpenAIRE |
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