CRMP-5-IgG Antibody: role in the bilateral uveitis with swollen disc
| Autor: | Lucía Mata-Moret, Emma Beltrán-Catalán, Enrique Cervera-Taulet, Laura Hernández-Bel, Amaya Fernandez-Diaz, María Luisa Hernández-Garfella, Francisco Puchades-Gimeno |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
optic neuritis
Systemic disease Pathology medicine.medical_specialty medicine.diagnostic_test genetic structures business.industry Autoantibody General Medicine Case Reports paraneoplastic conditions medicine.disease medicine.disease_cause Malignancy eye diseases Mediastinoscopy Autoimmunity small cell lung carcinoma medicine Optic neuritis Small Cell Lung Carcinoma sense organs business CRMP-5 IgG Uveitis |
| Zdroj: | Romanian Journal of Ophthalmology |
| ISSN: | 2501-2533 2457-4325 |
| Popis: | Autoimmunity against collapsin response-mediator protein-5 (anti-CRMP-5) has been associated with ocular inflammation in paraneoplastic syndrome. We present a 59-year-old Caucasian man with optic neuritis and vitreous cells in both eyes (OU), at different stages. Despite the fact that the patient did not have any systemic disease, we suspected a paraneoplastic syndrome and requested CRMP-5-IgG and a mediastinoscopy. After performing the tests, a small cell lung carcinoma was diagnosed. Autoantibody CRMP-5-IgG positivity and optic neuritis combined with vitreous inflammation was defined as a paraneoplastic entity, avoiding vitreous biopsy and allowing us to suspect malignancy before systemic symptoms appeared. |
| Databáze: | OpenAIRE |
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