Organogels based on amino acid derivatives and their optimization for drug release using response surface methodology
| Autor: | Beibei Hu, Yongshuai Jing, Xi Chen, Haipeng Yan, Yanping Sun, Yujuan Sun, Heran Li, Sanming Li |
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| Rok vydání: | 2023 |
| Předmět: |
Male
education Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) 02 engineering and technology Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Animals Tissue Distribution Response surface methodology Amino Acids chemistry.chemical_classification Drug Carriers General Medicine Risperidone 021001 nanoscience & nanotechnology Controlled release Combinatorial chemistry Box–Behnken design humanities Rats Amino acid Drug Liberation chemistry 030220 oncology & carcinogenesis Drug delivery Drug release Rheology 0210 nano-technology Drug carrier Gels Hydrophobic and Hydrophilic Interactions Biotechnology |
| DOI: | 10.6084/m9.figshare.11401503 |
| Popis: | Organogels are excellent drug carrier for controlled release. Organogels based on amino acid derivatives has been widely used in the area of drug delivery. In this study, a series of the organogel system based on amino acid derivatives gelators was designed and prepared to investigate the structure-property correlation in organogels. To investigate the factors that influence the property of drug release, we varied the formulation in the organogels: gelator structure, gelator concentration, volume of antigelation solvent, and drug loading. Through the Box–Behnken tests, the optimum organogel formulation in vitro was obtained. The self-healing properties of the organogel have been utilised for injection of a model lipophilic risperidone in situ, and sustained release of the drug has been studied over about one week in vivo. In conclusion, the gelation ability of gelators could be adjusted by the gelator structure. Gel property is related with the whole composition of the formulation. As drug carrier, the drug release property of organogels is affected by multiple factors. Our investigation of the gel release property will play a theoretical guiding role in the application in the in situ drug delivery system. |
| Databáze: | OpenAIRE |
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