Temporal evolution of cortical ensembles promoting remote memory retrieval
| Autor: | Marc Tessier-Lavigne, Lisa Fu, Eliza L. Adams, Drew Friedmann, Casey J. Guenthner, Liqun Luo, William E. Allen, Cindy D. Liu, Laura A. DeNardo |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Fear memory Memory Long-Term Computer science Conditioning Classical Prefrontal Cortex Mice Transgenic Early memory Article 03 medical and health sciences 0302 clinical medicine Memory Cortex (anatomy) medicine Animals Learning Prefrontal cortex Cerebral Cortex Neurons Integrases Extramural General Neuroscience Fear Remote memory Mice Inbred C57BL Tamoxifen 030104 developmental biology medicine.anatomical_structure Mental Recall Neuroscience 030217 neurology & neurosurgery PL activity |
| Zdroj: | Nature neuroscience |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/s41593-018-0318-7 |
| Popis: | Memories of fearful events can last a lifetime. The prelimbic (PL) cortex, a subregion of prefrontal cortex, plays a critical role in fear memory retrieval over time. Most studies have focused on acquisition, consolidation, and retrieval of recent memories, but much less is known about the neural mechanisms of remote memory. Using a new knock-in mouse for activity-dependent genetic labeling (TRAP2), we demonstrate that neuronal ensembles in the PL cortex are dynamic. PL neurons TRAPed during later memory retrievals are more likely to be reactivated and make larger behavioral contributions to remote memory retrieval compared to those TRAPed during learning or early memory retrieval. PL activity during learning is required to initiate this time-dependent reorganization in PL ensembles underlying memory retrieval. Finally, while neurons TRAPed during earlier and later retrievals have similar broad projections throughout the brain, PL neurons TRAPed later have a stronger functional recruitment of cortical targets. |
| Databáze: | OpenAIRE |
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