Clinical Study of Sodium Hypochlorite, Polymyxin B And Limewater Effect on MMP-3,-8,-9 In Apical Periodontitis
| Autor: | Lucas de Paula Ramos, Luciane Dias de Oliveira, Polyana das Graças Figueiredo Vilela, Cláudio Antonio Talge Carvalho, Marcia Carneiro Valera, Alessandra Sverberi Carvalho, Amjad Abu Hasna |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2019 |
| Předmět: |
Sodium Hypochlorite
Root canal Calcium hydroxide Dentistry Limewater chemistry.chemical_compound medicine Humans General Dentistry Polymyxin B Periodontitis Periapical periodontitis Root Canal Irrigants business.industry Chemistry Chlorhexidine medicine.disease medicine.anatomical_structure Matrix metalloproteinases Sodium hypochlorite Matrix Metalloproteinase 3 Dental Pulp Cavity business Periapical Periodontitis Root Canal Preparation medicine.drug |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Brazilian Dental Journal, Volume: 31, Issue: 2, Pages: 116-121, Published: 12 JUN 2020 Brazilian Dental Journal v.31 n.2 2020 Brazilian Dental Journal Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
| ISSN: | 1806-4760 |
| Popis: | This study aimed to evaluate sodium hypochlorite (NaOCl), limewater (LW), and Polymyxin B (PMB) as irrigants over MMP-3, MMP-8 and MMP-9. Thirty-three patients with apical periodontitis of single-rooted teeth were treated according to three-experimental groups (n=11): group-1: 2.5% NaOCl was used as irrigant; group-2: 2.5% NaOCl for the first two files and LW: [0.14% Ca(OH)2] for the last two files; group-3: 2.5% NaOCl for the first two files and PMB for the last two files. The association of Ca(OH)2 and CHX was used as an intracanal medication in all groups. Four root canal samplings (S) were collected: S1) immediately after access cavity; S2) after biomechanical preparation; S3) after EDTA application; and S4) after removal of the intracanal medication. After quantification of MMP-3, MMP-8, and MMP-9, the data were analyzed by Friedman and Kruskal-Wallis tests and completed by Dunn test (5%). Regardless the used irrigant, there was no difference in reducing MMP-3 or MMP-8 (P=0,5273, P=0,7048 respectively). However, in reducing MMP-9 (P=0,0246) the NaOCl group was the most effective followed by NaOCl+LW group and NaOCl+PMB group respectively. The intracanal medication [Ca(OH)2 + CHX] with the NaOCl and NaOCl+LW was effective in reducing MMP-8 (P |
| Databáze: | OpenAIRE |
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