SLC11A1polymorphisms in inflammatory bowel disease andMycobacterium aviumsubspeciesparatuberculosisstatus
| Autor: | John F. Pearson, Murray L. Barclay, Rebecca L. Roberts, Andrew S. Day, Lucy C. Stewart, Richard B. Gearry, Robert W Bentley |
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| Rok vydání: | 2010 |
| Předmět: |
Brief Article
Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Risk Assessment Inflammatory bowel disease White People Crohn Disease Gene Frequency Risk Factors Odds Ratio medicine Humans Immunologic Factors Genetic Predisposition to Disease Cation Transport Proteins Allele frequency SLC11A1 Crohn's disease Chi-Square Distribution Gastroenterology General Medicine medicine.disease biology.organism_classification Ulcerative colitis Mycobacterium avium subspecies paratuberculosis digestive system diseases Mycobacterium avium subsp. paratuberculosis Minor allele frequency Phenotype Case-Control Studies Immunology biology.protein Colitis Ulcerative New Zealand |
| Zdroj: | World Journal of Gastroenterology. 16:5727 |
| ISSN: | 1007-9327 |
| Popis: | AIM: To test for association of SLC11A1 with inflammatory bowel disease (IBD) and Mycobacterium avium subspecies paratuberculosis (MAP) status in a Caucasian cohort. METHODS: Five hundred and seven Crohn’s disease (CD) patients, 474 ulcerative colitis (UC) patients, and 569 healthy controls were genotyped for SLC11A1 1730G>A and SLC11A1 469+14G>C using pre-designed TaqMan® SNP assays. χ2 tests were applied to test for association of single nucleotide polymorphisms (SNPs) with disease, and the presence of MAP DNA. RESULTS: SLC11A1 1730G>A and SLC11A 1469+14G>C were not associated with CD, UC, or IBD. The SLC11A1 1730A minor allele was over-represented in patients who did not require immunomodulator therapy (P = 0.002, OR: 0.29, 95% CI: 0.13-0.66). The frequency of the SLC11A1 469+14C allele was higher in the subset of study participants who tested positive for MAP DNA (P = 0.02, OR: 1.56, 95% CI: 1.06-2.29). No association of SLC11A1 1730G>A with MAP was observed. CONCLUSION: Although SLC11A1 was not associated with IBD, association with MAP suggests that SLC11A1 is important in determining susceptibility to bacteria implicated in the etiology of CD. |
| Databáze: | OpenAIRE |
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