Selective laser sintering of porous tissue engineering scaffolds from poly(L: -lactide)/carbonated hydroxyapatite nanocomposite microspheres
| Autor: | Min Wang, Siu Hang Lee, W. L. Cheung, Wing Yuk Ip, Wen You Zhou |
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| Rok vydání: | 2007 |
| Předmět: |
Nanostructure
Materials science Hot Temperature Surface Properties Polyesters Biomedical Engineering Biophysics Sintering Bioengineering law.invention Biomaterials chemistry.chemical_compound Tissue engineering law Materials Testing Composite material Porosity Lactide Nanocomposite Tissue Engineering Lasers Microspheres Nanostructures Polyester Selective laser sintering chemistry Bone Substitutes Hydroxyapatites |
| Zdroj: | Journal of materials science. Materials in medicine. 19(7) |
| ISSN: | 1573-4838 |
| Popis: | This study focuses on the use of bio-nanocomposite microspheres, consisting of carbonated hydroxyapatite (CHAp) nanospheres within a poly(L: -lactide) (PLLA) matrix, to produce tissue engineering (TE) scaffolds using a modified selective laser sintering (SLS) machine. PLLA microspheres and PLLA/CHAp nanocomposite microspheres were prepared by emulsion techniques. The resultant microspheres had a size range of 5-30 microm, suitable for the SLS process. Microstructural analyses revealed that the CHAp nanospheres were embedded throughout the PLLA microsphere, forming a nanocomposite structure. A custom-made miniature sintering platform was installed in a commercial Sinterstation((R)) 2000 SLS machine. This platform allowed the use of small quantities of biomaterials for TE scaffold production. The effects of laser power; scan spacing and part bed temperature were investigated and optimized. Finally, porous scaffolds were successfully fabricated from the PLLA microspheres and PLLA/CHAp nanocomposite microspheres. In particular, the PLLA/CHAp nanocomposite microspheres appeared to be promising for porous bone TE scaffold production using the SLS technique. |
| Databáze: | OpenAIRE |
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